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halohydrin formation reaction : ウィキペディア英語版
Halohydrin

In organic chemistry a halohydrin (also a haloalcohol or β-halo alcohol) is a functional group in which a halogen and a hydroxyl are bonded to adjacent carbon atoms, which otherwise bear only hydrogen or hydrocarbyl groups (e.g. 2-chloroethanol, 3-chloropropane-1,2-diol). The term only applies to saturated motifs, as such compounds like 2-chlorophenol would not normally be considered halohydrins.
Halohydrins may be categorized as chlorohydrins, bromohydrins, flurohydrins or iodohydrins depending on the halogen present.
==Synthesis==
Halohydrin are usually prepared by treatment of an alkene with a halogen (often bromine), in the presence of water.〔(【引用サイトリンク】 work = (Virtual Textbook of Organic Chemistry ) )〕 The reaction is a form of electrophilic addition, similar to the halogen addition reaction and proceeds with anti addition, leaving the newly added X and OH groups in a trans configuration. The basic chemical equation for this reaction is as follows:
:C=C + X2 + H2O → X-C-C-OH (X represents a halogen, either Cl or Br).
When bromination is desired, ''N''-bromosuccinimide is preferable to bromine because fewer side-products are produced.
Halohydrins may also be prepared from the reaction of an epoxide with a hydrohalic acid, or a metal halide.

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
ウィキペディアで「Halohydrin」の詳細全文を読む



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